MATRIXYL®3000

Comparison after 56 days of treatment with MATRIXYL® 3000
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A peptide compound consists of two groups of peptides: Pal-GHK and Pal-GQPR. These peptides function in a similar manner to Vitamin C and in many cases, their performance exceeds the functioning of the vitamin’s natural version. The matrikines (messengers of cutaneous restructuration and repair) firm the skin while stimulating the production of collagen to repair age damage.

Furthermore, they strengthen the membranes and the protective skin barriers, by activation of neosynthesis of extracellular matrix macromecules to facilitate skin cells to withstand the damaging effects of ultraviolet radiation.

Synthesis of matrix macromolecules:

Study of the stimulation of synthesis of extracellular matrix components by fibroblasts incubated for 72 hours with MATRIXYL®3000 (1, 3, 5%).

Study of the regulation of dermal and epidermal genes by matrikines from MATRIXYL®3000, using DNA-Array technique on reconstructed epidermis and on fibroblast culture.

Results: Matrikines from Matrixyl®3000 show a complementary gene activation profile with respect to the major mechanisms involved in cutaneous restructuration.

Effect on skin tone and elasticity

2 groups of 23 volunteers aged between 39 and 74 years / Twice daily application to one half of the face a cream containing 3% of Matrixyl ®3000 or 3% of Matrixyl against placebo, for 2 months. Assessment of elasticity and tone by cytometry on the same group as above.

Results: With Matrixyl ®3000, skin tone and elasticity displayed a major and significant improvement.

Anti-wrinkle efficacy

2 groups of 23 volunteers aged between 39 and 74 / Twice daily application to one half of the face a cream containing 3% Matrixyl® 3000 or 3% Matrixyl against placebo, for 2 months. Assessment of the anti-wrinkle efficacy by profilometry and photography compared to T-0.